NDLI: Hyaluronic Acid‐Functionalized Electrospun Polyvinyl Alcohol/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications

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Hyaluronic Acid‐Functionalized Electrospun Polyvinyl Alcohol/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications

Content Provider	Semantic Scholar
Author	Zhao, Yili Fan, Zhangyu Shen, Mingwu Shi, Xiangyang
Copyright Year	2015
Abstract	Capturing circulating tumor cells (CTCs) with sufficient sensitivity and specificity in vitro is of paramount importance for early cancer diagnosis. Here a facile approach to immobilizing hyaluronic acid (HA) onto electrospun polyvinyl alcohol/polyethyleneimine (PVA/PEI) nanofibers for capturing cancer cells overexpressing CD44 receptors is reported. In this study, electrospun PVA/PEI nanofibers were crosslinked using glutaraldehyde vapor, covalently conjugated with HA via N-(3-dimethy-laminopropyl)-N′-ethylcarbodiimide/N-hydroxysuccinimide coupling reaction, followed by neutralization of the remaining fiber surface PEI amines via acetylation. The formed nanofibers were characterized using different techniques. It is shown that the HA-modified PVA/PEI nanofibers with a mean diameter of 459.7 nm possess a smooth and uniform fibrous morphology, similar to the PVA/PEI nanofibers without HA modification. The HA-modified PVA/PEI nanofibers display good cytocompatibility and hemocompatibility as confirmed by cell viability, hemolysis, and anticoagulant assays. Importantly, with the modified HA, the nanofibers exhibit superior capability to capture CD44 receptor-overexpressing cancer cells. The developed HA-modified PVA/PEI nanofibers may hold a great promise to be applied for capturing CTCs for cancer diagnosis applications.
Starting Page	1500256
Ending Page	1500256
Page Count	1
File Format	PDF HTM / HTML
DOI	10.1002/admi.201500256
Volume Number	2
Alternate Webpage(s)	http://pdf-s3.xuebalib.com:1262/xuebalib.com.34858.pdf
Alternate Webpage(s)	https://doi.org/10.1002/admi.201500256
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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