NDLI: Durable In Vitro Cartilage Repair and Functional Load Transmission with MSC-Seeded Hyaluronic Acid Hydrogels

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Durable In Vitro Cartilage Repair and Functional Load Transmission with MSC-Seeded Hyaluronic Acid Hydrogels

Content Provider	Semantic Scholar
Author	McKay, Mauck Rl
Copyright Year	2011
Abstract	INTRODUCTION: The role of articular cartilage is to provide a low friction surface that resists wear while distributing stresses in the demanding joint environment. As the tissue possesses little intrinsic healing capacity, any damage that occurs is progressive, and may culminate in the need for total joint replacement. Regenerative strategies, including microfracture and autologous chondrocyte implantation (ACI), result in the formation of functionally inferior tissue that does not transmit load and may fail due to lack of integration to adjacent cartilage. We have previously demonstrated that mesenchymal stem cells (MSCs) undergo chondrogenesis in hyaluronic acid (HA) hydrogels, and that these engineered constructs can integrate with native tissue in an in vitro cartilage defect model [1]. However, the integration strength of the engineered repair was less than that of cartilage-cartilage repair controls [1]. Therefore, the objective of this study was to enhance functional integration of stem cell seeded HA constructs via increases in seeding density and enhanced in vitro culture conditions. Further, we sought to expand our testing modalities to consider the durability of integration (after repeated loading) and the contribution of the maturing repair material to the compressive properties of the entire construct.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.ors.org/Transactions/58/1753.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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