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Chairman's introduction: what can we expect to learn from genomics?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mathers, John C. |
| Copyright Year | 2004 |
| Abstract | The year 2003 is the 50th anniversary of the publication of Crick and Watson’s landmark paper suggesting a double helix structure for DNA (Watson & Crick, 1953) and the year in which the Human Genome Mapping Project has been completed. In the last 50 years, there has been an exponential expansion of biological research using genetics-based concepts and tools, with an increasing focus on mechanistic studies at the molecular level. Initial efforts to reveal the information in DNA have focused on sequence analysis and on understanding chromosomal structure. The sequence of bases within DNA provides the primary information store for each cell by encoding the genes that provide the blueprint for making proteins, the main structural components and workhorses of the cell. However, there is much more information within chromatin associated with the way that the DNA strand is packaged and with the proteins (histones) around which it is wrapped (for further discussion, see p. 2). In contrast to DNA sequence information that is essentially fixed for any given individual and determines the amino acid sequence and structure of proteins, these higher levels of information are involved in regulating gene expression at a given instant and may be influenced by the cell’s environment. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1079/PNS2003322 |
| PubMed reference number | 15070434 |
| Journal | Medline |
| Volume Number | 63 |
| Issue Number | 1 |
| Alternate Webpage(s) | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/9AF73880C0AB472354772A73978F1461/S0029665104000011a.pdf/chairmans_introduction_what_can_we_expect_to_learn_from_genomics.pdf |
| Alternate Webpage(s) | https://doi.org/10.1079/PNS2003322 |
| Journal | The Proceedings of the Nutrition Society |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
