El síndrome de apneas obstructivas del sueño en la obesidad: un conspirador en la sombra

Content Provider	Semantic Scholar
Author	Salvador, Javier Iriarte, Jorge Silva, Camilo Ambrosi, Javier Gómez Caballero, Alberto Díez
Copyright Year	2004
Abstract	Summary The obstructive sleep apnoea syndrome (OSAS) is caused by upper airway collapse during sleep. These episodes are associated with recurrent oxyhaemoglobin desaturations and arousals which lead to disruption of the sleep pattern and cognitive deterioration. Factors such as age, male sex, menopause, tobacco and alcohol consump- tion and anatomic abnormalities are demonstrated risk factors for OSAS development. Obesity, specially of abdominal type, is also a very strong predictor of OSAS, increasing the risk of apnoea by ten times. OSAS prevalence may reach 80% and 50% en males and females with morbid obesity respectively. OSAS induces sympathoexcitation, insulin resistance, renin-angiotensin system ac- tivation, oxidative stress, endothelial dysfunction, hypercoagulability and reduction of fibrinolysis leading to hypertension and increased cardiovascular risk. The best diagnostic procedure is polysomnography. Obesity treatment is followed by a dramatic improvement in OSAS. Weight loss of 10% results in reductions of apnoea index by 26%. Application of a positive pressure system is a very effective treatment for OSAS which reduces the apnoea index and improves cardiovascu- lar risk and cognitive impairment.
Starting Page	55
Ending Page	62
Page Count	8
File Format	PDF HTM / HTML
Volume Number	48
Alternate Webpage(s)	http://www.arintegral.com.mx/archivos/sindrome_apneas_en_obesidad.pdf
Alternate Webpage(s)	http://dadun.unav.edu/bitstream/10171/35447/1/Rev%20Med%20Univ%20Navarra%202004%20salvador%5B1%5D.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article