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Euphorbia Helioscopia Inhibits The LPS-Induced Pro-Inflammatory Response in RAW 264.7 Cells Via The NF-Κb and MAPK Pathway
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yang, Eun-Jin Lee, Juyeong Hyun, Chang-Gu |
| Copyright Year | 2016 |
| Abstract | Previous studies have characterized the total polyphenolic contents, antioxidant activity, tyrosinase, elastase, and NO production of halophytes. Halophytes are distributed among many countries; however, it has not been properly utilized. In this study, we investigated the inhibitory effect of halophyte Euphorbia helioscopia (E.H.) on the LPS-induced inflammatory response in RAW 264.7 macrophages by MTT assay, NO assay, ELISA, and western blot analysis. Our results demonstrate that E.H. reduced LPS-induced NO and PGE2 in addition to pro-inflammatory mediators, IL-6, IL-1β and TNF-α. Furthermore, E.H. inhibited LPS-induced activation of NF-κB, via IκBα degradation and phosphorylation of JNK and ERK. Our data suggest that the E.H. anti-inflammatory effect is a result of inhibition of LPS-induced NO, PGE2, IL-6, IL-1β, and TNF-α production via downregulation of the NF-κB and MAPK pathway. |
| Starting Page | 2873 |
| Ending Page | 2879 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.13005/ojc/320605 |
| Volume Number | 32 |
| Alternate Webpage(s) | http://www.orientjchem.org/download/26469/ |
| Alternate Webpage(s) | https://doi.org/10.13005/ojc%2F320605 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
