NDLI: Sexual Dysfunction in First-Episode Schizophrenia Patients : Results from EUFEST

Please wait, while we are loading the content...

Sexual Dysfunction in First-Episode Schizophrenia Patients : Results from EUFEST

Content Provider	Semantic Scholar
Author	Malik, Péter Kemmler, Georg Hummer, Martina Riecher-Rössler, Anita Kahn, René S. Fleischhacker, W. Wolfgang
Copyright Year	2016
Abstract	Sexual dysfunctions (SD) occur frequently in schizophrenia patients and have a huge impact on quality of life and compliance. They are often associated with antipsychotic medication. Nicotine consumption, negative or depressive symptoms and physical illness are also discussed as contributing factors. Data on SD in first-episode schizophrenia patients are scarce. As part of the European First Episode Schizophrenia Trial (EUFEST), first-episode schizophrenia patients were randomly assigned to five medication groups. We assessed SD by analyzing selected items from the Udvalg for Kliniske Undersugelser (UKU) at baseline and five following visits. Differences between antipsychotics were small for all SDs and fairly little change in the prevalence of SDs was seen over the course of the study. A significantly larger increase of amenorrhea and galactorrhea was seen with amisulpride than with the other medications. In men, higher age, more pronounced Positive and Negative Symptom Scale (PANSS) general psychopathology symptoms and higher plasma prolactin levels predicted higher rates of erectile and ejaculatory dysfunctions. PANSS negative symptoms and higher age were predictors for decreased libido. In women, higher prolactin plasma levels were identified as a predictor of amenorrhea. PANSS negative symptoms predicted decreased libido. All evidence taken together underscores the influence of the disease schizophrenia itself on sexual functioning. In addition, there is a strong correlation between the prolactin-increasing properties of amisulpride and menstrual irregularities.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://core.ac.uk/download/pdf/19742775.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in