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Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hanuš, Lumír Ondřej Tchilibon, Susanna Ponde, Datta E. Breuer, Aviva Fride, Ester Mechoulam, Raphael |
| Copyright Year | 2005 |
| Abstract | (-)-Cannabidiol (CBD) is a major, non psychotropic constituent of cannabis. It has been shown to cause numerous physiological effects of therapeutic importance. We have reported that CBD derivatives in both enantiomeric series are of pharmaceutical interest. Here we describe the syntheses of the major CBD metabolites, (-)-7-hydroxy-CBD and (-)-CBD-7-oic acid and their dimethylheptyl (DMH) homologs, as well as of the corresponding compounds in the enantiomeric (+)-CBD series. The starting materials were the respective CBD enantiomers and their DMH homologs. The binding of these compounds to the CB(1) and CB(2) cannabinoid receptors are compared. Surprisingly, contrary to the compounds in the (-) series, which do not bind to the receptors, most of the derivatives in the (+) series bind to the CB(1) receptor in the low nanomole range. Some of these compounds also bind weakly to the CB(2) receptor. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/B416943C |
| PubMed reference number | 15750656 |
| Journal | Medline |
| Volume Number | 3 |
| Issue Number | 6 |
| Alternate Webpage(s) | https://1d7u564dod7i2q96m533sblk-wpengine.netdna-ssl.com/wp-content/uploads/2018/11/09-OBCh-3-1116-2005.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/B416943C |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
