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The relative importance of inositol 1,4,5-trisphosphate, 1,2-diacylglycerol and phosphatidic acid in mediating human platelet activation by thrombin
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lapetina, Eduardo G. Watson, Steve P. |
| Copyright Year | 1984 |
| Abstract | Thrombin-induced platelet activation can be correlated with formation of three potential bioactive agents (i.e. , second messengers), namely, inositol 1,4,5-trisphosphate, 1,2-diacylglycerol and phosphatidic acid. The present article reviews the relative importance of these three second messengers. It is suggested that both 1,2-diacylglycerol and phosphatidic acid may be of importance in activating protein kinase C in platelets, and that inositol 1,4,5-trisphosphate and possibly lysophosphatidic acid, may be of importance in mobilizing Ca++. It is concluded that thrombin-induced platelet activation occurs through the synergistic interaction of Ca++ and protein kinase C activation. |
| Starting Page | 127 |
| Ending Page | 131 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/978-1-349-17613-7_14 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/978-1-349-17613-7_14 |
| Alternate Webpage(s) | https://doi.org/10.1007/978-1-349-17613-7_14 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
