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pH-sensitive Photoluminescence of CdSe/ZnSe/ZnS Quantum Dots in Human Ovarian Cancer Cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sun, Yinghua Liang, Chi-Hui Chong, Suet Ying Christin |
| Copyright Year | 2007 |
| Abstract | The photoluminescence of mercaptoacetic acid (MAA)-capped CdSe/ZnSe/ZnS semiconductor nanocrystal quantum dots (QDs) in SKOV-3 human ovarian cancer cells is pH-dependent, suggesting applications in which QDs serve as intracellular pH sensors. In both fixed and living cells the fluorescence intensity of intracellular MAA-capped QDs (MAA QDs) increases monotonically with increasing pH. The electrophoretic mobility of MAA QDs also increases with pH, indicating an association between surface charging and fluorescence emission. MAA dissociates from the ZnS outer shell at low pH, resulting in aggregation and loss of solubility, and this may also contribute to the MAA QD fluorescence changes observed in the intracellular environment. |
| Starting Page | 2872 |
| Ending Page | 2878 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://chems.usc.edu/assets/002/51286.pdf |
| Alternate Webpage(s) | http://chems.usc.edu/assets/002/51247.pdf |
| PubMed reference number | 18985164v1 |
| Volume Number | 111 |
| Issue Number | 7 |
| Journal | The journal of physical chemistry. C, Nanomaterials and interfaces |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Fluorescence Iodine I 124-cRGDY-PEG-C Dots Malignant neoplasm of ovary Nanocrystalline Materials Quantum Dots Semiconductors Technetium Tc 99m Aggregated Albumin mercaptoacetic acid ovarian neoplasm |
| Content Type | Text |
| Resource Type | Article |
