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Cytoplasmic actin in postsynaptic structures at the neuromuscular junction
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hall, Zach W. Lubit, Beverly W. Schwartz, James H. |
| Copyright Year | 1981 |
| Abstract | We used an antibody prepared against Aplysia (mollusc) body-wall actin that specifically reacts with certain forms of cytoplasmic actin in mammalian cells to probe for the presence of actin at the neuromuscular junction. Immunocytochemical studies showed that actin or an actinlike molecule is concentrated at neuromuscular junctions of normal and denervated adult rat muscle fibers. Actin is present at the neuromuscular junctions of fibers of developing diaphragm muscles as early as embryonic day 18, well before postsynaptic folds are formed. These results suggest that cytoplasmic actin may play a role in the clustering or stabilization of acetylcholine receptors at the neuromuscular junction. |
| Starting Page | 789 |
| Ending Page | 792 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 7026578v1 |
| Volume Number | 90 |
| Journal | The Journal of cell biology |
| Alternate Webpage(s) | http://jcb.rupress.org/content/jcb/90/3/789.full.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Actins Aplysia Cholinergic Receptors Concentrate Dosage Form Mollusca Muscle Fibers Neuromuscular Diseases Neuromuscular Junction Tissue fiber |
| Content Type | Text |
| Resource Type | Article |