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Antifertility Activity of Simple Ascidian , Microcosmus exasperatus Heller , 1878 R Research
| Content Provider | Semantic Scholar |
|---|---|
| Author | Meenakshi, Vaidyanathapuram Kesavan Gomathy, Sudalaimuthu Paripooranaselvi, Manuelraj Senthamarai, S. Rani Karuppan Chamundeswari, Pothiraj |
| Copyright Year | 2014 |
| Abstract | Increase in life expectancy and decrease in death rate, as a result of recent advances in the domain of medicine, pharmaceuticals and public health has led to a rapid population explosion. Plant based natural products have been used as antifertility agents from time immemorial. But due to various reasons they are exploited and the resources are depleting. Hence there is an urgent need for the search of an effective and safe male antifertility agent from other sources. The present investigation was designed to find out the effect of ethanol extract of simple ascidian Microcosmus exasperatus on the fertility of male albino rats. For the study, experimental animals were divided in to four groups of five each. Group I received normal saline and served as control. The second, third and fourth group of animals were administrated with the extracts at a dose of 50, 100, 150 mg/kg body weight respectively for a period of 14 days. Significant decrease in the weight of body, testis and the accessory sex organs were noted. A dose related reduction in sperm count of testis, epididymis, motility and increase in the level of abnormal sperms were observed. The serum biochemical parameters and liver marker enzymes did not show any significant variations. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://globalresearchonline.net/journalcontents/v24-1/41.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
