Inhibition of replication of normal adrenocortical cells in culture by adrenocorticotropin.

Content Provider	Semantic Scholar
Author	Ramachandran, Jayalakshmi Suyama, Akira
Copyright Year	1975
Abstract	Adrenocorticotropic hormone (ACTH) inhibited [3H]thymidine incorporation in normal adrenocortical cells of adult rats in culture, with a concomitant increase in corticosterone production and a characteristic retraction of cells. Both dibutyryl cyclic AMP and an analog of ACTH, which produces virtually no cyclic AMP, inhibited DNA synthesis and stimulated steroid production. ACTH inhibited the proliferation of adrenocortical cells obtained from suckling rats as well as the cells obtained from the capsular tissue of adult rat adrenal glands, whereas insulin caused a stimulation of DNA synthesis. These results suggest that the major role of ACTH is to induce the transformation of the undifferentiated cells of the adrenal gland into functional fasciculata cells and that the proliferation of adrenocortical cells may be under control of factors other than ACTH.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.72.1.113
PubMed reference number	164010
Journal	Medline
Volume Number	72
Issue Number	1
Alternate Webpage(s)	http://www.pnas.org/content/72/1/113.full.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.72.1.113
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article