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High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients
| Content Provider | Semantic Scholar |
|---|---|
| Author | Aierken, Nijiati Shi, Huijuan Zhou, Yu Shao, Nan Zhang, Jin Shi, Yawei Yuan, Zhong-yu Lin, Ying |
| Copyright Year | 2017 |
| Abstract | BACKGROUND To investigate the role of Programmed death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in tumor recurrence and metastasis of Chinese patients suffering from triple negative breast cancer (TNBC). METHODS PD-L1 immunohistochemistry was performed on 215 TNBCs. Also, the prevalence of TILs correlated the expression of PD-L1 and TILs with clinical outcomes. Kaplan-Meier and the model analyses of univariate Cox proportional hazards were utilized to compare the survival of patients with positive PD-L1 expression with those with negative PD-L1 expression. RESULTS The median follow-up time was 67.7 months (range: 7-159 months). PD-L1-positive breast cancer patients had significantly longer disease-free survival (DFS) and Overall survival (OS) compared with PD-L1-negative patients (P=0.046; P=0.019) in TNBC. The presence of increased stromal lymphocytic infiltrates (STILs) was significantly associated with overall survival (P=0.026). The model analysis of univariate Cox proportional hazards showed that PD-L1 and STILs were independent prognostic factors for tumor prognosis. CONCLUSIONS Our study found that high levels of PD-L1 could be expressed in TNBC, which was correlated with the prevalence of TILs. |
| Starting Page | 1172 |
| Ending Page | 1179 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ijbs.com/v13p1172.pdf |
| PubMed reference number | 29104508v1 |
| Alternate Webpage(s) | https://doi.org/10.7150/ijbs.20868 |
| DOI | 10.7150/ijbs.20868 |
| Journal | International journal of biological sciences |
| Volume Number | 13 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biomarkers, Tumor Breast Carcinoma CD274 wt Allele Infiltration L1 childhood acute lymphoblastic leukemia Leukemia, T-Cell Ligands Lymphocytes, Tumor-Infiltrating Malignant neoplasm of breast Mammary Neoplasms Overall Survival Parkinson Disease Patients Recurrent tumor Triple Negative Breast Neoplasms lymphocytic infiltrate |
| Content Type | Text |
| Resource Type | Article |
