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Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wu, Mona K. |
| Copyright Year | 1999 |
| Abstract | Both linear and cyclic derivatives of the cyclic 12-amino-acid antimicrobial peptide bactenecin were designed based on optimization of amphipathicity and charge location. In general, increasing the number of positive charges at the N and C termini and adding an extra tryptophan residue in the loop not only increased the activities against both gram-positive and gram-negative bacteria but also broadened the antimicrobial spectrum. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cmdr.ubc.ca/bobh/wp-content/uploads/2016/10/199.-Wu-1999.pdf |
| Alternate Webpage(s) | http://aac.asm.org/content/43/5/1274.full.pdf |
| PubMed reference number | 10223951v1 |
| Volume Number | 43 |
| Issue Number | 5 |
| Journal | Antimicrobial agents and chemotherapy |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Gram-Negative Bacteria Thioctic Acid Tryptophan bactenecin gram |
| Content Type | Text |
| Resource Type | Article |
