NDLI: Highly enantioselective [4+2] annulation via organocatalytic Mannich-reductive cyclization: one-pot synthesis of functionalized piperidines.

Content Provider	Semantic Scholar
Author	Kumar, Indresh Ramaraju, Panduga Mir, Nisar A. Singh, Deepika Gupta, Vivek Kumar Rajnikant
Copyright Year	2013
Abstract	A new method for one-pot synthesis of 2,3-substituted piperidine from N-PMP aldimine and aqueous glutaraldehyde via formal [4+2] cycloaddition is reported. This reaction involves organocatalytic direct Mannich reaction-reductive cyclization with high yields (up to 90%) and excellent enantioselectivities (up to >99%). The practicability of this method is also shown at a gram scale as well as through the synthesis of functionalized (-)-anabasine.
File Format	PDF HTM / HTML
DOI	10.1039/c3cc42431f
PubMed reference number	23689916
Journal	Medline
Volume Number	49
Issue Number	50
Alternate Webpage(s)	http://www.rsc.org/suppdata/cc/c3/c3cc42431f/c3cc42431f.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c3cc42431f
Journal	Chemical communications
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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