Loading...
Please wait, while we are loading the content...
Similar Documents
Responsiveness to aspirin in patients with unstable angina pectoris by whole blood aggregometry.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Jianjie Dong, Hang Jian, Zhao Wu, Xiao Juan Zhao, Xionghu Yu, Seung Youn Huang, Li Chu |
| Copyright Year | 2009 |
| Abstract | AIMS To evaluate aspirin responsiveness in patients with unstable angina pectoris (UAP) by whole blood aggregometry. Another goal was to differentiate aspirin-resistant patients into pharmacokinetic or pharmacodynamic type. METHODS We measured platelet aggregation by determining impedance values in 70 normal volunteers and 104 UAP patients on aspirin (100 mg/day > or = 7 days) in four inducing conditions [1 microg/ml collagen, 2 microg/ml collagen, 5 micromol/l adenosine diphosphate (ADP) and 10 micromol/l ADP]. We calculated a cut-off value based on data from normal volunteers to define aspirin responsiveness in cases. Then, the correlation and agreement between the results in the four conditions was analysed to choose a preferred inducing condition for identification of aspirin resistance. Aliquots from all samples were incubated with 0.1 mmol/l aspirin and measured again for aspirin-resistant classification. RESULTS Aspirin resistance was observed in 38 patients (36.5%), 51 patients (49.0%), 67 patients (64.4%) and 67 patients (64.4%), respectively, for 1 microg/ml collagen, 2 microg/ml collagen, 5 micromol/l ADP and 10 micromol/l ADP among 104 patients. Collagen at low concentration was suggested as a preferred agent for detecting aspirin inhibitory effect according to the coefficient of sensitivity. After incubation, only three among 38 aspirin-resistant patients showed normal platelet aggregation and were classified into pharmacodynamic type. CONCLUSIONS In the presence of collagen at low concentration (1 microg/ml), the prevalence of aspirin resistance is about 36.5% in UAP patients, and according to a classification specific for resistant patients, most of the aspirin 'resistance' is just because of pharmacokinetic issues. |
| Starting Page | 1263 |
| Ending Page | 1264 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cardiovascular.xqhospital.com.cn:8050/uploadfile/2009/11/23/20091123103419.pdf |
| PubMed reference number | 19222626v1 |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1742-1241.2008.01976.x |
| DOI | 10.1111/j.1742-1241.2008.01976.x |
| Journal | International journal of clinical practice |
| Volume Number | 63 |
| Issue Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenosine Diphosphate Angina Pectoris Aspirin Blood Platelet Disorders Blood Platelets Classification Micromole Patients Pharmacodynamics Unstable Medical Device Problem incubated |
| Content Type | Text |
| Resource Type | Article |
