NDLI: Plasma N-terminal B type natriuretic peptide as an Indicator of Long-term Survival After Acute Myocardial Infarction : Comparison With Plasma Mid-regional Pro-atrial Natriuretic Peptide-Leicester Acute Myocardial Infarction Peptide ( LAMP ) Study

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Plasma N-terminal B type natriuretic peptide as an Indicator of Long-term Survival After Acute Myocardial Infarction : Comparison With Plasma Mid-regional Pro-atrial Natriuretic Peptide-Leicester Acute Myocardial Infarction Peptide ( LAMP ) Study

Content Provider	Semantic Scholar
Author	Khan, Sohail Qamar Dhillon, Onkar S. Kelly, Dominic Squire, Iain B. Struck, Joachim Quinn, Paulene A. Morgenthaler, Nils G. Bergmann, Andreas Davies, Joan E. Ng, Leong Loke
Copyright Year	2008
Abstract	word count 208) Objectives Our aim was to assess the prognostic value of MR-proANP in patients post acute myocardial infarction (AMI). Background Multimarker strategies may assist risk stratification post-AMI. Midregional Pro-Atrial Natriuretic Peptide (MR-proANP) is a newly described stable fragment of N-terminal Pro-Atrial Natriuretic Peptide. We compared the prognostic value of MR-proANP and an established marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) post-AMI. Methods We recruited 983 consecutive post-AMI patients (720 men, median [range] age 65[24-95] years) in a prospective study with follow-up over 343[0-764] days. Results Plasma MR-proANP was raised in patients who died (n=101) compared to survivors (median [range] pmol/L, 310[48-1150] vs. 108[4.9-1210], P<0.0001). Using Cox modelling log10MRproANP (HR 3.87) and log10NT-proBNP (HR 3.25) were significant independent predictors of death. In patients stratified by NT-proBNP in the highest quartile (> ~5900 pmol/L), MRproANP in the top quartile (~330 pmol/L) was associated with poorer outcome (P<0.0001). Findings were similar for heart failure as an individual endpoint. However neither marker predicted recurrent AMI. Conclusions The A and B-type natriuretic systems are activated post AMI. MR-proANP is a powerful predictor of adverse outcome especially in those with an elevated NT-proBNP. MR-proANP may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy targeting the natriuretic neurohormonal pathway.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://core.ac.uk/download/pdf/191993.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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