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Axotomy-dependent stimulation of choline acetyltransferase activity by exogenous mouse nerve growth factor in adult rat basal forebrain
| Content Provider | Semantic Scholar |
|---|---|
| Author | Williams, Lawrence R. Jodelis, Karen S. Donald, Melody R. |
| Copyright Year | 1989 |
| Abstract | Transection of the adult rat dorsal fornix and fimbria (F-F) induced a sensitivity of the cholinergic neurons in the medial septum and diagonal band (MS/DB) to exogenous mouse nerve growth factor (mNGF). Continuous infusion of mNGF for two weeks after complete unilateral F-F aspiration resulted in a stimulation of choline acetyltransferase (ChAT)-specific activity in precise micro-dissections of the MS/DB ipsilateral to the transection to a level that was 200% higher than that measured in normal adult animals. This supranormal stimulation of ChAT activity reached plateau levels after 10 days of NGF infusion and was dose-dependent with an E.D.50 equal to 120 ng/day. Administration of mNGF had no effect on the ChAT activity in the MS/DB of normal animals or animals with a unilateral transection of only the supracallosal dorsal septo-hippocampal pathway. Partial transection experiments indicated that a predominent pathway for cholinergic neurons potentially sensitive to exogenous mNGF runs in the paramedian F-F. Administration of mNGF also induced a stimulation of ChAT activity in dissections of the caudate-putamen both ipsi- and contralateral to the infusion cannula. This indicates that unlike the cholinergic projection neurons of the MS/DB, adult cholinergic striatal interneurons are sensitive to exogenous NGF without prior axotomy. |
| Starting Page | 243 |
| Ending Page | 256 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(89)91103-7 |
| PubMed reference number | 2790481 |
| Journal | Medline |
| Volume Number | 498 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0006899389911037 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0006899389911037?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2889%2991103-7 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
