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Study of Ulcer Protective Effect of Ipomea batatas (L.) Dietary Tuberous Roots (Sweet Potato)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sathish, Rengarajan Rani, Mukta Natarajan, Kumaresapillai |
| Copyright Year | 2012 |
| Abstract | Peptic ulcer is one of the most prevalent gastrointestinal disorder, commonly occurs in develop ed countries. The present work was carried out to evaluate antiulcer effect of Ipomoea batatas (L) d tuberous roots.The Ethanolic extract of Ipomoea batatas(EEIB) was prepared by dynamic maceration for 7 days at room temperature using 70% ethanol(V/V). The antiulcer activity was evaluated by the Pylorus Ligation (PL) and cold restraint stress (C RS) Induced Ulcer models.Male Wisterrats weredivided into fourgroups of 3 animals each for both models and received Normal saline10ml/kg, Famotidine 20 mg/kg, EEIB at 250 & 500mg/kg respectively. After 1 h of Standard and test treatments pyloric ligat ion was performed and gastric pH,total acidity, free acidity,total protein, pepsin, ulcer score and ulcer index were determined. In CRS model, drugs were administered orally 30 min prior to subjecting the animals to cold stress(2∞C for 3 hours), thenulcer score and ulcer index were determined. Results were mean ± SEM (n=3) and analysed using one way ANOVA followed by Dunnett test. p < 0.05 was considered significant when compared with the toxicant groups.In PL model EEIB significantly ( p < 0.01) reduced the ulcer index by55.24% and 61.45% at 250 & 500 mg/kg doses respectively. In CRS model, both the doses of EEIB significantly ( p < 0.01) reduced ulcer index by51.35% (250 mg/kg) and 75.68% (500 mg/kg).The Ipomoea batatas roots possess anti ulcer activ ity as evidenced by its significant inhibitory effects on PL and CRS induced ulcers. |
| Starting Page | 36 |
| Ending Page | 39 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Volume Number | 11 |
| Alternate Webpage(s) | http://ijpt.iums.ac.ir/article-1-234-en.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
