NDLI: High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy

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High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy

Content Provider	Semantic Scholar
Author	Freitas, Betânia De Jesus E Silva De Almendra Lloret, Gustavo Rafaini Visacri, Marília Berlofa Tuan, Bruna Taliani Amaral, Laís Sampaio Baldini, Daniele Sousa, Vanessa Marcílio De Castro, Laís Lima De Aguiar, Jordana Rayane Sousa Pincinato, Eder De Carvalho Mazzola, Priscila Gava Moriel, Patricia
Copyright Year	2015
Abstract	BACKGROUND Phase I of this study was aimed at comparing the profiles of oxidative stress biomarkers in patients with history of nonmelanoma skin cancer (NMSC), previously treated with surgery, to the healthy subjects. Phase II aimed to evaluate the effects of supplementary antioxidant therapy on the levels of biomarkers in the case group. MATERIALS AND METHODS In Phase I, oxidative stress biomarkers were measured in blood samples obtained from 24 healthy subjects and 60 patients with history of NMSC previously treated with surgery. In Phase II, the 60 patients with history of NMSC were randomized into two subgroups, one receiving placebo (n = 34) and the other (n = 26) receiving vitamin C, vitamin E, and zinc supplementation for 8 weeks, followed by reevaluation of biomarkers. RESULTS In Phase I, patients with history of NMSC showed increased plasma concentrations of all biomarkers, but only 15-F2t-isoprostane was significantly higher than in the healthy subjects. Risk of NMSC increased by 4% for each additional 1 pg/mL increase in 15-F2t-isoprostane. In Phase II, supplementation did not significantly reduce levels of oxidative stress biomarkers. CONCLUSION Patients with history of NMSC had significantly high 15-F2t-isoprostane plasma levels; supplementation did not result in significant reduction of oxidative stress biomarkers. This trial was registered with ClinicalTrials.gov (ID NCT02248584).
File Format	PDF HTM / HTML
DOI	10.1155/2015/963569
PubMed reference number	26509174
Journal	Medline
Volume Number	2015
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/b6/17/BMRI2015-963569.PMC4609811.pdf
Alternate Webpage(s)	http://downloads.hindawi.com/journals/bmri/2015/963569.pdf
Alternate Webpage(s)	https://doi.org/10.1155/2015%2F963569
Journal	BioMed research international
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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