NDLI: Eradication of Helicobacter pylori reduces metachronous gastric cancer after endoscopic resection of early gastric cancer.

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Eradication of Helicobacter pylori reduces metachronous gastric cancer after endoscopic resection of early gastric cancer.

Content Provider	Semantic Scholar
Author	Seo, Ji Yeon Lee, Dong Ryun Cho, Yuri Lee, Dong Hyeon Oh, Sang Jo, Hyun Jin Shin, Cheol Min Lee, Sang Hyub Park, Young Soo Hwang, Jin Hyeok Kim, Jin Wook Jeong, Sook Hyang Kim, Nayoung Jung, Hyun Chae
Copyright Year	2013
Abstract	BACKGROUND/AIMS Although some studies have shown improvement of precancerous lesions and a decrease of metachronous gastric cancer after eradication of H. pylori, this is still controversial. METHODOLOGY We identified 74 patients with early gastric cancer and who had their H. pylori eradicated after undergoing endoscopic resection between September, 2003 and September, 2010. The endoscopic biopsy specimens, campylobacter-like organism test and urea breath test were reviewed. Relapse of gastric cancer was assessed from medical records. RESULTS Among the 74 patients, 61 (82.4%) were successfully eradicated. The mean duration of follow-up was 27.2±18.7 months. H. pylori colonization, neutrophil infiltration, mononuclear cell infiltration and intestinal metaplasia decreased after eradication (all p<0.05). For all the patients, metachronous gastric cancer showed a decrease in the eradicated group, but this did not reach statistical significance (odds ratio: 0.36, 95% CI: 0.08-1.70, p=0.189). However, when restricted to those who were followed-up for more than 18 months, metachronous gastric cancer was significantly decreased in the eradicated group (odds ratio: 0.108, 95% CI: 0.016-0.726, p=0.035). CONCLUSIONS Eradication of H. pylori decreased precancerous lesions, and when following-up for more than 18 months, eradication also reduced metachronous gastric cancer.
File Format	PDF HTM / HTML
DOI	10.5754/hge12929
PubMed reference number	23165228
Journal	Medline
Volume Number	60
Issue Number	124
Alternate Webpage(s)	http://www.ekjm.org/upload/42846236.pdf
Alternate Webpage(s)	http://www.kaim.or.kr/upload/workshop/62/S-1.pdf
Alternate Webpage(s)	https://doi.org/10.5754/hge12929
Journal	Hepato-gastroenterology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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