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Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chan, M-H Chen, H-H |
| Copyright Year | 2006 |
| Abstract | BACKGROUND Group I metabotropic glutamate receptors (mGluRs) have been reported to regulate N-methyl-d-aspartate (NMDA) receptor function in various brain regions. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate NMDA antagonists such as PCP and MK-801-induced behavioural responses. In the present study, the role of group I mGluRs on ketamine- and propofol-induced general anaesthesia was examined. METHODS Mice were pretreated with various doses of the group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (DHPG), selective mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), mGluR1 antagonist 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt) and mGluR5 antagonist MPEP followed by administration of ketamine (120 mg kg(-1)) or propofol (140 mg kg(-1)) to induce anaesthesia. The duration of loss of righting reflex was recorded. RESULTS DHPG and CHPG antagonized and MPEP potentiated ketamine-induced anaesthesia in a dose-dependent manner. CPCCOEt was ineffective. However, propofol-induced anaesthesia was not affected after manipulating mGluR1 and mGluR5 receptors. CONCLUSIONS mGluR5 receptors play an important role in modulation of anaesthesia induced by ketamine, but not propofol. |
| Starting Page | 597 |
| Ending Page | 601 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/bja/ael046 |
| PubMed reference number | 16531447 |
| Journal | Medline |
| Volume Number | 96 |
| Issue Number | 5 |
| Alternate Webpage(s) | https://watermark.silverchair.com/ael046.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAjgwggI0BgkqhkiG9w0BBwagggIlMIICIQIBADCCAhoGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMqWHsvdZqM1HE20GEAgEQgIIB6733JzmGds-uQuDOlp8YPmuI_TKebNfdtUwgRvlFzbDRNK1cp5aNat7NYD-ApcueXd-YErRsD5kXK_NAenLpaEAhgU5uC9b_w6bXYAFetvVLGdxFh37BqFuyiRy6-0RsKlk_uDF0c8BPqsh-xZ5PDt0HZiwakllgvjd7qirZ26oFtn8FSqsH-Uy_dr5QXFVFC3KqseQ2cuGZUFbY1OCpXCqx8NpKKzT_PBQWAc7mf2DlfrH239phyHZjVzfw25wqkugzYPF1nTbAWVFGX7BwsTeBm9IzQi8tJbiBys0koZ_OXY_IJxKjzOSdZcSD34HfTdP2SlIuiPO0GwUUWeZgbyrjK_64jLG740lxFo0HOM3BtM7ccosToNmCOFqBlFXH6mEK5szPURpDWlYipeQ5tPGjqNWkxdslTBDMzrZwKLMo2TLX22EmIcRpcD3ycrEOHPJOXfwzMZFB0vwKc1Ih4u8_HxZRwqE-gCoHSilovRTG_flEZ_zyo0mpG5qMTC3txpf7D1HkixjHBvi4sBbhp6qaFOlQ_polTrsQCJPTNLn9AGjEyMInUYzanyyEG-R5cHLCJoa7HaBO9DRkgwYPsLvMBUxSnfSPef7lybL43fESnoT1exAzNlq5ouc9mC1hYGvNXtMV2Oh31qLW |
| Alternate Webpage(s) | https://doi.org/10.1093/bja%2Fael046 |
| Journal | British journal of anaesthesia |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
