Estudo evolutivo das crianças expostas ao HIV e notificadas pelo núcleo de vigilância epidemiológica do HCFMRP-USP

Content Provider	Semantic Scholar
Author	Silva, Adriana Fernandes Da
Copyright Year	2004
Abstract	Silva, ANF. Evolutive study of children exposed to HIV and notified by the Nucleus of Epidemiological Surveillance of HCFMRP-USP. 2004. 70p. Dissertação (Mestrado) – Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2004. The objective of the present study was to evaluate the evolution of children born to HIV-positive mothers or mothers with AIDS at the University Hospital, Faculty of Medicine of Ribeirão Preto, during the period from 1986 to 2001. Information was obtained about prenatal prophylaxis and infant prophylaxis at birth, and about serologic reversal, seropositivity and survival. Of the 680 participants, 67 (9.8%) were infected, 520 (76.5%) were not infected, and no information was available for 93 (13.7%) infants who were lost to followup. Prophylaxis during pregnancy occurred in 144 women with the use of mono prophylaxis (21.2%) and in 77 with the use of two or more drugs (11.3%), and 459 (67.5%) received no prophylaxis. Among the newborns, 205 (30.1%) received only AZT, 134 (19.7%) were medicated with AZT+SMX/TMP, and 341 (50.1%) had not carried trough prophylaxis. Thirty-nine children died (5.7%), 559 (82.2%) continued to live, and for 82 (120%) the information was lost. The death rate was considerably more elevated among the children who did not receive prophylaxis (9.7%) compared to those who received only AZT (2.9%). No death occurred among the 134 children had prophylaxis with AZT+SMX/TMP. Death rates varied according to time, reaching 9.5% during the preprophylaxis period (1986/1995) and falling to 2.7% between 1996 and 2001 Twenty-two deaths occurred among the 67 HIV-infected individuals (33.8%), a much higher value than detected among the 520 non-infected individuals (4 deaths, 0.8%). The median times for serological reversal were 589 days for the infants born between 1986 and 1995 and 451 days for those born from 1996 to 2001. The survival curves demonstrated an evident favoring of individuals submitted to some type of prophylaxis, indicating that therapeutic intervention has brought unquestionable gains for infants born to HIV-positive mothers or mothers with AIDS.
File Format	PDF HTM / HTML
DOI	10.11606/D.17.2004.tde-10102006-102046
Alternate Webpage(s)	https://teses.usp.br/teses/disponiveis/17/17139/tde-10102006-102046/publico/MsSilvaANF1.pdf
Alternate Webpage(s)	https://doi.org/10.11606/D.17.2004.tde-10102006-102046
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article