NDLI: Anti-idiotypic antibody as a potential candidate vaccine for Neisseria meningitidis serogroup B.

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Anti-idiotypic antibody as a potential candidate vaccine for Neisseria meningitidis serogroup B.

Content Provider	Semantic Scholar
Author	Youn, Ju Ho Choi, In-Hong Nahm, Moon H. Kim, Se-Jong Shin, Jeon-Soo
Copyright Year	2005
Abstract	Sepsis and meningitis caused by Neisseria meningitidis serogroup B (NMGB) are serious diseases in infants and young adults, but no effective vaccine is available. The capsular polysaccharide (PS) of NMGB has poor immunogenicity and a structural similarity to polysialic acid (PSA) on neuronal tissue that may elicit autoantibodies. Using HmenB3, a protective and nonautoreactive monoclonal antibody (MAb) to NMGB capsular PS, we produced an anti-idiotypic MAb, Naid60, which mimics the capsular PS of NMGB. We produced an anti-anti-idiotypic MAb, MoB34, by using the immunogenic site on Naid60 responsible for inducing the anti-NMGB PS antibody response. MoB34 elicited the complement-mediated killing of representative strains of serogroup B meningococci. MoB34 did not bind to CHP-134, a neuroblastoma cell line expressing alpha(2-8) PSA, or to mouse brain cryosections at a high concentration. Naid60-keyhole limpet hemocyanin immunization inhibited the growth of live NMGB in intraperitoneally challenged mice; in contrast, three of five control mice developed bacteremia. Thus, Naid60 has an immunogenic site that elicits antibodies with bactericidal activity against NMGB and no autoimmunity to PSA. We suggest that the immunogenic region of Naid60 is a candidate for the development of a new vaccine against NMGB.
File Format	PDF HTM / HTML
DOI	10.1128/IAI.73.10.6399-6406.2005
PubMed reference number	16177311
Journal	Medline
Volume Number	73
Issue Number	10
Alternate Webpage(s)	http://iai.asm.org/content/73/10/6399.full.pdf
Alternate Webpage(s)	https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/151111/1/T200500918.pdf
Alternate Webpage(s)	https://doi.org/10.1128/IAI.73.10.6399-6406.2005
Journal	Infection and immunity
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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