NDLI: Effects of recombinant GM-CSF on the blast cells of acute myeloblastic leukemia.

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Effects of recombinant GM-CSF on the blast cells of acute myeloblastic leukemia.

Content Provider	Semantic Scholar
Author	Hoang, T. Nara, Nobuo Wong, Gyc Clark, S. Minden, Mark D. Mcculloch, E. A.
Copyright Year	1986
Abstract	The effects of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) were compared to those of media conditioned by the continuous bladder carcinoma line, HTB9 (HTB9-CM), using three criteria. First, both GM-CSF and HTB9-CM stimulated blast colony formation in methylcellulose cultures, patient-to-patient variations were seen in the dose-response curves, and GM-CSF was effective, but less so that HTB9-CM. Second, GM-CSF also enhanced growth of blast progenitors in suspension culture, indicating its capacity to support self-renewal. GM-CSF was as effective as HTB9-CM in the production of adherent cells during the growth of blast cells in suspension, a finding that is interpreted to mean that GM-CSF also supports postdeterministic events in blast differentiation. Finally, colonies growing in the presence of GM-CSF were not phenotypically different than those stimulated by HTB9-CM.
File Format	PDF HTM / HTML
DOI	10.1182/blood.v68.1.313.313
PubMed reference number	3487359
Journal	Medline
Volume Number	68
Issue Number	1
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/68/1/313.full.pdf?sso-checked=true
Alternate Webpage(s)	https://doi.org/10.1182/blood.v68.1.313.313
Journal	Blood
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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