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Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bouwmeester, Hans Gerrits, Mirjam Roozemond, John G. Snapper, Jolanda Ronken, Eric Ree, Jan M. Van |
| Copyright Year | 2007 |
| Abstract | There is evidence for neurodevelopment disturbances in schizophrenia. In rats, a neonatal basolateral amygdala lesion induces behavioural features in adults reminiscent of the symptomatology of schizophrenia. Dopamine plays a key role in the pathogenesis of schizophrenia, and cannabis use has been implicated in the risk for developing schizophrenia. The effects of an excitotoxic, bilateral basolateral amygdala lesion on postnatal days 7 or 21 were compared when the rats were adult. The behavioural response to a novelty challenge and the level of dopamine receptors and cannabinoid receptors in the brain using in-vitro autoradiography was determined. In brain tissue punches concentrations of monoamines and metabolites were determined by high-performance liquid chromatography. The neonatal lesion, but not the later lesion induced behavioural hyperactivity and biochemical effects. The neonatal lesion reduced the density of dopamine D2-like, but not D3-, and less markely D1-like receptors and increased dopamine turnover. These effects were observed in the mesolimbic, but not in the striatal regions. In contrast, density of cannabinoid receptors was increased in the striatal, but not the mesolimbic regions of these animals. Noradrenergic neurotransmission was reduced in both regions. The present findings contribute to the idea that the neonatal basolateral amygdala lesion induces features in adults reminiscent of the neurodevelopmental disturbances in schizophrenia, with a focus on the amygdala-prefrontal cortex-nucleus accumbens circuit. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ijnp.oxfordjournals.org/content/ijnp/10/6/727.full.pdf |
| PubMed reference number | 17076936v1 |
| Volume Number | 10 |
| Issue Number | 6 |
| Journal | The international journal of neuropsychopharmacology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amygdaloid structure Autoradiography Cannabinoids Cannabis Cell Nucleus Dopamine Receptor Hyperactive behavior Metabolite Neurodevelopmental Disorders Nucleus Accumbens Prefrontal Cortex Schizophrenia Synaptic Transmission cannabinoid receptor central amygdalar nucleus monoamine |
| Content Type | Text |
| Resource Type | Article |
