NDLI: Synthesis, Antimicrobial and Antitubercular Activities of Some Novel Carboxamide Derivatives of 2-Quinolones

Content Provider	Semantic Scholar
Author	Kumar, Abhishek Fernandes, Jennifer Kumar, Pankaj
Copyright Year	2014
Abstract	A series of novel substituted N-(3-acetyl-2-oxoquinolin-1(2H)-yl)benzamide (AJQC1AJQC12) have been synthesized upon refluxing 3-acetyl-1-amino-quinolin-2-one and substituted benzoic acid in the presence of dry redistilled pyridine and silicon tetrachloride as coupling agent. 3-acetyl-1-amino-quinolin-2-one (AJQ1-AJQ12) were synthesized from substituted 3-acetyl coumarin upon refluxing with hydrazine hydrate and ethanol. The structures of the final carboxamide derivatives were confirmed by IR, 1H NMR and mass spectra. The synthesized compounds were screened for their antimicrobial activity by tube dilution method and antitubercular activity by microplate Alamar blue assay. Most of the compounds have exhibited promising antibacterial, antifungal and antitubercular activities.
Starting Page	1993
Ending Page	1997
Page Count	5
File Format	PDF HTM / HTML
DOI	10.13005/ojc/300462
Volume Number	30
Alternate Webpage(s)	http://www.orientjchem.org/pdf/vol30no4/OJCV030I04P1993-1997.pdf
Alternate Webpage(s)	https://doi.org/10.13005/ojc%2F300462
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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