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Efeito vasodilatador do extrato metanólico de Erythroxylum caatingae Plowman sobre anéis mesentéricos de ratos espontaneamente hipertensos (SHR)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Reis, Milena Ramos Albuquerque, Jamile Morais De Tavares, Josean Fechine Silva, Darizy Flávia |
| Copyright Year | 2012 |
| Abstract | Introduction: Erythroxylum caatingae Plowman (ETC) has revealed the presence of several alkaloids with biological activity. Objective: Evaluate the potential antihypertensive action of methanol extract from ETC species in superior mesenteric artery rings isolated from spontaneously hypertensive rats (SHR). Methods: Pharmacological tests were performed in vitro and the vasorelaxant effect of ETC (0.01-300 μg/mL) was observed. Results: In isolated mesenteric rings with a functional and intact endothelium, pre-contracted with phenylephrine (PHE) (1 μM), ETC induced relaxation [EC50 = 14.49 (20.5 29.2) μg/mL; MR = 110.11 ± 2.4%, n = 7] in a concentration dependent manner. This effect was not attenuated after removal of the vascular endothelium [EC50 = 27.41 (21.1 35.6) μg/mL; MR = 116.7 ± 8.0%, n = 7, p<0.05]. These results suggest that the vasodilator response induced by ETC is independent of endothelium derived vasoactive factors. Therefore, subsequent experiments were performed in endothelium removed mesenteric rings. In rings pre-contracted with serotonin, ETC had an increased pharmacological potency when compared to rings pre-contracted with PHE [EC50 = 9.22 (5.8 14.6) μg/mL, n = 11, p<0.001], but not significant difference with respect to its maximum effect (MR = 112.97 ± 3.5%, n = 11, p<0.05). In rings pre-contracted with a depolarizing solution of KCl (60 mM), the concentration-response curve for ETC was not significantly different to that obtained in rings pre-contracted with PHE [EC50 = 20.76 (16.2 26.6) μg/mL, MR = 106.94 ± 3.6%, n = 8, p<0.05]. Conclusion: Taken together, these findings suggest that ETC promotes vasodilation in mesenteric rings from SHR animals, independent of the presence of the vascular endothelium, and these effects have a more potent impact on vascular tone of upon activation serotonin receptors, when compared to other vasoconstricting agents. |
| Starting Page | 123 |
| Ending Page | 128 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.9771/cmbio.v11i2.6671 |
| Volume Number | 11 |
| Alternate Webpage(s) | https://portalseer.ufba.br/index.php/cmbio/article/download/6671/4564 |
| Alternate Webpage(s) | https://doi.org/10.9771/cmbio.v11i2.6671 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
