NDLI: Thiosulfate-Hydrogen Peroxide Redox Oscillator as pH Driver for Ribozyme Activity in the RNA World

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Thiosulfate-Hydrogen Peroxide Redox Oscillator as pH Driver for Ribozyme Activity in the RNA World

Content Provider	Semantic Scholar
Author	Ball, Rowena Brindley, John
Copyright Year	2015
Abstract	The RNA world of more than 3.7 billion years ago may have drawn on thermal and pH oscillations set up by the oxidation of thiosulfate by hydrogen peroxide (the THP oscillator) as a power source to drive replication. Since this primordial RNA also must have developed enzyme functionalities, in this work we examine the responses of two simple ribozymes to a THP periodic drive, using experimental rate and thermochemical data in a dynamical model for the coupled, self-consistent evolution of all reactants and intermediates. The resulting time traces show that ribozyme performance can be enhanced under pH cycling, and that thermal cycling may have been necessary to achieve large performance gains. We discuss three important ways in which the dynamic hydrogen peroxide medium may have acted as an agent for development of the RNA world towards a cellular world: proton gradients, resolution of the ribozyme versus replication paradox, and vesicle formation.
Starting Page	133
Ending Page	147
Page Count	15
File Format	PDF HTM / HTML
DOI	10.1007/s11084-015-9448-z
PubMed reference number	26341510
Journal	Medline
Volume Number	46
Alternate Webpage(s)	http://www.biorxiv.org/content/biorxiv/early/2015/06/10/020693.full.pdf
Alternate Webpage(s)	https://www.biorxiv.org/content/biorxiv/early/2015/06/10/020693.full.pdf
Alternate Webpage(s)	http://biorxiv.org/content/biorxiv/early/2015/06/10/020693.full.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s11084-015-9448-z
Journal	Origins of Life and Evolution of Biospheres
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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