NDLI: Gene expression profiles of the fibroblasts from breast tumors and normal tissue compared with the tumor expression profiles.

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Gene expression profiles of the fibroblasts from breast tumors and normal tissue compared with the tumor expression profiles.

Content Provider	Semantic Scholar
Author	Hussain, Syed S. Qattan, Amal Nirmal, Maimoona S. Almalik, Osama Al-Tweigeri, Taher A. Tulba, Asma M. Amer, Suad M. Bin
Copyright Year	2006
Abstract	OBJECTIVE The study was designed to examine whether the gene expression profiles of fibroblast cell lines, established from the tumor and the normal tissue from the same breast, exhibit any similarities with the profiles of the original tissues. METHODS Fibroblast cell lines were established from invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS) of the breast and the adjacent normal tissues. Isolated total RNA from the cell lines and tissues were used to prepare labeled cDNA which was hybridized to Becton Dickinson Atlas microarrays for obtaining profiles of expressed genes. The profiles of tumors and cell lines were compared. This study was carried out at King Faisal specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia, during 2004 and 2005. RESULTS Alterations of expression of most of the genes in the tissues were not detectable in the cell lines. The expression of a lower number of genes was altered in DCIS compared with that in IDC tumors. CONCLUSION Although the fibroblasts discharge important functions, their gene expression profiles do not represent the breast tissue to the extent that any prognostic decisions could be made.
File Format	PDF HTM / HTML
PubMed reference number	16598321
Journal	Medline
Volume Number	27
Issue Number	4
Alternate Webpage(s)	http://www.smj.org.sa/index.php/smj/article/download/3593/1367
Journal	Saudi medical journal
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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