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Hindlimb unloading has a greater effect on cortical compared with cancellous bone in mature female rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Allen, Matthew R. Bloomfield, Susan A. |
| Copyright Year | 2003 |
| Abstract | This study was designed to determine the effects of 28 days of hindlimb unloading (HU) on the mature female rat skeleton. In vivo proximal tibia bone mineral density and geometry of HU and cage control (CC) rats were measured with peripheral quantitative computed tomography (pQCT) on days 0 and 28. Postmortem pQCT, histomorphometry, and mechanical testing were performed on tibiae and femora. After 28 days, HU animals had significantly higher daily food consumption (+39%) and lower serum estradiol levels (-49%, P = 0.079) compared with CC. Proximal tibia bone mineral content and cortical bone area significantly declined over 28 days in HU animals (-4.0 and 4.8%, respectively), whereas total and cancellous bone mineral densities were unchanged. HU animals had lower cortical bone formation rates and mineralizing surface at tibial midshaft, whereas differences in similar properties were not detected in cancellous bone of the distal femur. These results suggest that cortical bone, rather than cancellous bone, is more prominently affected by unloading in skeletally mature retired breeder female rats. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jap.physiology.org/content/jap/94/2/642.full.pdf |
| PubMed reference number | 12391029v1 |
| Volume Number | 94 |
| Issue Number | 2 |
| Journal | Journal of applied physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Animal for breeding Autopsy Bone Cysts Bone Density Bone structure of tibia Cancellous Bone Compact bone Estradiol Hindlimb Suspension Lower Extremity Osteogenesis Tomography, Emission-Computed X-Ray Computed Tomography |
| Content Type | Text |
| Resource Type | Article |
