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Polymorphism of 2-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyridazin-1-yl)acetic acid with two monoclinic modifications: crystal structures and Hirshfeld surface analyses
| Content Provider | Semantic Scholar |
|---|---|
| Author | Daoui, Said Baydere, Cemile Chelfi, Tarik Kalai, Fouad El Dege, Necmi Karrouchi, Khalid Benchat, Noureddine |
| Copyright Year | 2020 |
| Abstract | Two polymorphs of the title compound, C19H16N2O3, were obtained from ethano-lic (polymorph I) and methano-lic solutions (polymorph II), respectively. Both polymorphs crystallize in the monoclinic system with four formula units per cell and a complete mol-ecule in the asymmetric unit. The main difference between the mol-ecules of (I) and (II) is the reversed position of the hy-droxy group of the carb-oxy-lic function. All other conformational features are found to be similar in the two mol-ecules. The different orientation of the OH group results in different hydrogen-bonding schemes in the crystal structures of (I) and (II). Whereas in (I) inter-molecular O-H⋯O hydrogen bonds with the pyridazinone carbonyl O atom as acceptor generate chains with a C(7) motif extending parallel to the b-axis direction, in the crystal of (II) pairs of inversion-related O-H⋯O hydrogen bonds with an R 2 2(8) ring motif between two carb-oxy-lic functions are found. The inter-molecular inter-actions in both crystal structures were analysed using Hirshfeld surface analysis and two-dimensional fingerprint plots. |
| Starting Page | 432 |
| Ending Page | 437 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1107/s2056989020002406 |
| PubMed reference number | 32148889 |
| Journal | Medline |
| Volume Number | 76 |
| Alternate Webpage(s) | https://journals.iucr.org/e/issues/2020/03/00/wm5541/wm5541.pdf |
| Alternate Webpage(s) | http://journals.iucr.org/e/issues/2020/03/00/wm5541/wm5541.pdf |
| Alternate Webpage(s) | https://doi.org/10.1107/s2056989020002406 |
| Journal | Acta crystallographica. Section E, Crystallographic communications |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
