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Circulating oxidized LDL is associated with increased waist circumference independent of body mass index in men and women.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Weinbrenner, Tanja Schröder, Helmut Escurriol, Verónica Fito, Montserrat Elosúa, Roberto Marrugat, Jaume Covas, Maria-Isabel |
| Copyright Year | 2006 |
| Abstract | BACKGROUND Obesity is associated with oxidative stress, and the oxidation of LDL is thought to play a crucial role in the generation of atherosclerotic lesions. OBJECTIVE The objective was to describe the association of waist circumference (WC) and body mass index (BMI; in kg/m2) with plasma circulating oxidized LDL (ox-LDL) and C-reactive protein (CRP). DESIGN This cross-sectional study included data for circulating ox-LDL and CRP from a subpopulation of 586 men and women enrolled in a population-based survey conducted in 2000 in Girona, Spain. Multivariate analysis was performed to describe the independent association of WC and BMI with ox-LDL and CRP. RESULTS Multivariate logistic regression analysis adjusted for lifestyle, educational level, and dietary confounders showed a direct association of WC (quartile distribution) and BMI categories with ox-LDL (P for linear trend = 0.002) and CRP (P for linear trend = 0.004). Subjects in the top quartile of WC and with a BMI > 29.9 were at high risk of elevated circulating concentrations of ox-LDL and CRP. Further adjustment for cardiovascular disease risk factors did not substantially modify these associations. The risk of high ox-LDL concentrations in overweight (BMI = 25.0-29.9) or obese (BMI > or = 30) subjects with a WC < 102 cm (men) or < 88 cm (women) was not significantly different from that in normal-weight subjects with these WCs. In contrast, overweight or obese subjects with higher WCs (WC > or = 102 cm for men and > or = 88 cm for women) were at significantly higher risk of increased ox-LDL. CONCLUSION High WC was associated with high concentrations of ox-LDL independently of BMI in the study population. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://invitalab.de/wp-content/uploads/2011/03/Literatur_oxLDL.pdf |
| Alternate Webpage(s) | https://www.redheracles.net/media/upload/research/pdf/164000461320676802.pdf |
| Alternate Webpage(s) | https://watermark.silverchair.com/znu00106000030.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAawwggGoBgkqhkiG9w0BBwagggGZMIIBlQIBADCCAY4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMQSL0vGz9PnMjFWGaAgEQgIIBX61bz9I9pmUC4cZBM5yr_75stH_GpZ5FiMLqzOwPBt6tS5K2oJBVyeLgqZebWH82R6J47C_SkKeVtLL4PyUH177n9kgyqsHuZnB7iwiVuhGRnexPAxukkNY572fwmgVmqxRKnMCyXptsocrzJn_w8V0Dg0gWSorZzULdN4WfCPlFbVjQHuSWhxHJzXGDq5L18gxoh5c8gWLWHxPeuyVaTEQIkf9Oibw5jZWmaRF_MFOIc4u1WLM_brTNkkYgx5QOaNgKWzcnfO7qu25Kfrf0W2PoC5V6GmQUqFW6tFTf3pp1SGGzRdW7MmhBCGX4foUfW5iNdldnalLylm9GkI7sPbzZqmU7gPh9vRgdAIJ7_CtoEUvZMh6x_Fi283mVjX5XTdWiDAYgNIan3JD-N32tDq_ca_N9l9qrRxFAF4CoLYewG-PyiAx1T81GnRcNIIse21FK7u98eZ58E4xDFc3BDw |
| PubMed reference number | 16400046v1 |
| Volume Number | 83 |
| Issue Number | 1 |
| Journal | The American journal of clinical nutrition |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Atherosclerosis Body mass index Cardiovascular Diseases Categories HCRT gene Kilogram Per Square Meter Mental association Obesity Overweight Oxidative Stress Waist Circumference Water consumption oxidation |
| Content Type | Text |
| Resource Type | Article |
