Loading...
Please wait, while we are loading the content...
Similar Documents
Synthesis of 4'α -C Phenyl-Branched Carbocyclic Nucleoside Using Ring-Closing Metathesis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hee, Joon Ko, Ok Hyun |
| Copyright Year | 2003 |
| Abstract | and Ok Hyun KoCollege of Pharmacy, Chosun University, Gwangju 501-759, KoreaReceived May 28, 2003An efficient synthetic route for preparing novel 4'α-C phenyl branched carbocyclic nucleoside is described.The installation of phenyl group at the 4'-position of carbocyclic nucleoside was successfully accomplished viaa sequential [3,3]-sigmatropic rearrangement and ring-closing metathesis (RCM) beginning from simpleketone such as 2-hydroxy acetophenone.Key Words : Carbocyclic nucleoside, Antiviral agents, [3,3]-Sigmatropic rearrangement, Ring-closingmetathesisIntroductionCarbocyclic nucleosides are a group of compounds thatare structurally similar to natural nucleosides where thefuranose oxygen is replaced by a methylene group. Thereplacement of the furanose ring oxygen by carbon is ofparticular interest because the resulting carbocyclic nucleo-sides possess a greater metabolic stability to phosphorylase, |
| Starting Page | 1289 |
| Ending Page | 1292 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.5012/bkcs.2003.24.9.1289 |
| Volume Number | 24 |
| Alternate Webpage(s) | http://ocean.kisti.re.kr/downfile/volume/chemical/JCGMCS/2003/v24n9/JCGMCS_2003_v24n9_1289.pdf |
| Alternate Webpage(s) | https://doi.org/10.5012/bkcs.2003.24.9.1289 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |