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Clash of the titans
| Content Provider | Semantic Scholar |
|---|---|
| Author | Galande, Sanjeev |
| Copyright Year | 1996 |
| Abstract | Soon after the discovery of the structure of DNA, it was suggested that the flow of genetic information is unidirectional and that DNA serves as a template for making RNA molecules, which are subsequently used as templates for assembling proteins. This pathway for the flow of genetic information was referred to as the 'central dogma' of molecular biology. Barring a few exceptions where this flow of information is reversed, the central dogma has retained its validity. Its most important feature is that each of these molecules requires a template for its synthesis. Thus, DNA acts as its own template and therefore self replicates, and all RNA molecules are synthesized on DNA templates. Both these processes take advantage of base complementarity; a feature that is central to the structure of DNA and RNA. All proteins are determined by RNA templates by employing a universal code called the genetic code. For survival of a species it is essential that the genetic information is utilised in an accurate manner and therefore nature has evolved distinct machineries for the faithful copying of all these templates into their corresponding products. called DNA polymerase. The process of copying DNA into RNA is referred to as transcription, and is mediated by a multi-subunit enzyme called RNA polymerase. The DNA and RNA polymerases together with a battery of accessory proteins, constitute the respective copying machinery. The fact that both the replication and transcription machineries utilise the same DNA template poses some mechanistic problems for the cell. |
| Starting Page | 102 |
| Ending Page | 104 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/BF02838868 |
| Alternate Webpage(s) | http://www.biophan.com/dmdocuments/MRI_HHL%20042006.pdf |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/BF02838868 |
| Alternate Webpage(s) | https://doi.org/10.1007/BF02838868 |
| Volume Number | 1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
