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Potential risk of mulberry-drug interaction: modulation on P-glycoprotein and cytochrome P450 3A.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hsu, Pei-Wen Shia, Chi-Sheng Lin, Shiuan-Pey Chao, Pei-dawn Lee Juang, S. J. Hou, Yu-Chi |
| Copyright Year | 2013 |
| Abstract | Mulberry is a fruit containing polyphenol antioxidants. Cyclosporine (CSP), a potent immunosuppressant with a narrow therapeutic range, is widely used in transplant patients. This study investigated the effect of co-administration of mulberry on the bioavailability of CSP, a probe drug of P-glycoprotein (P-gp)/cytochrome P450 3A4 (CYP 3A4), in rats and relevant mechanisms. CSP (2.5 mg/kg) was orally administered with and without a single dose or the seventh dose of mulberry (2 g/kg) to rats. The results showed that a single dose of mulberry significantly decreased the area under the curve of concentration (AUC(0-540)) and the maximum blood concentration (Cmax) of CSP by 53.2 and 65.8%, respectively. Repeated dosing of mulberry significantly decreased the AUC(0-540) and Cmax of CSP by 23.7 and 39.7%, respectively. Mechanism studies indicated that mulberry significantly increased the activities of P-gp and CYP 3A. In conclusion, mulberry significantly reduced the bioavailability of CSP through activating the functions of P-gp and CYP 3A. |
| Starting Page | 305 |
| Ending Page | 318 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www2.cmu.edu.tw/~pharmacy/doc/research/paper_2013.pdf |
| Alternate Webpage(s) | http://pharmacy.cmu.edu.tw/doc/research/paper_2013.pdf |
| PubMed reference number | 23590720v1 |
| Alternate Webpage(s) | https://doi.org/10.1021/jf3052384 |
| DOI | 10.1021/jf3052384 |
| Journal | Journal of agricultural and food chemistry |
| Volume Number | 61 |
| Issue Number | 18 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antioxidants Area Under Curve Cmax Cyclosporine Cytochrome P450 Drug Interactions Immunosuppressive Agents Oral cavity Patients polyphenols |
| Content Type | Text |
| Resource Type | Article |
