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Localization of metastasis within the sentinel lymph node biopsies: a predictor of additional axillary spread of breast cancer?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Alvarenga, César Augusto Santos, César Cabello Dos Alvarenga, Marcelo Paravidino, Paula Itagyba Morais, S. S. Brenelli, Henrique Benedito Carvalho, Filomena Marino De |
| Copyright Year | 2013 |
| Abstract | PURPOSE To explore the relationship between morphological characteristics and histologic localization of metastasis within sentinel lymph nodes (SLN) and axillary spread in women with breast cancer. METHODS We selected 119 patients with positive SLN submitted to complete axillary lymph node dissection from July 2002 to March 2007. We retrieved the age of patients and the primary tumor size. In the primary tumor, we evaluated histologic and nuclear grade, and peritumoral vascular invasion (PVI). In SLNs we evaluated the size of metastasis, their localization in the lymph node, number of foci, number of involved lymph nodes, and extranodal extension. RESULTS Fifty-one (42.8%) patients had confirmed additional metastasis in non-sentinel lymph nodes (NLSN). High histologic grade, PVI, intraparenchymatous metastasis, extranodal neoplastic extension and size of metastasis were associated with positive NLSN. SLN metastasis affecting the capsule were associated to low risk incidence of additional metastasis. After multivariate analysis, PVI and metastasis size in the SLN remained as the most important risk factors for additional metastasis. CONCLUSIONS The risk of additional involvement of NSLN is higher in patients with PVI and it increases progressively according the histologic localization in the lymph node, from capsule, where the afferent lymphatic channel arrives, to the opposite side of capsule promoting the extranodal extension. Size of metastasis greater than 6.0 mm presents higher risk of additional lymph node metastasis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.scielo.br/pdf/rbgo/v35n11/v35n11a02.pdf |
| PubMed reference number | 24419528v1 |
| Volume Number | 35 |
| Issue Number | 11 |
| Journal | Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Axillary lymph node group Biopsy Histopathologic Grade Lymphadenopathy Mammary Neoplasms Patients Peripheral Vascular Intervention Promotion (action) Sentinel Lymph Node Vascular Diseases Vascular Invasion Assessment axillary lymph node dissection lymph nodes primary tumor |
| Content Type | Text |
| Resource Type | Article |
