NDLI: A two-current model for the dynamics of cardiac membrane.

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A two-current model for the dynamics of cardiac membrane.

Content Provider	Semantic Scholar
Author	Mitchell, Colleen C. Schaeffer, David G.
Copyright Year	2003
Abstract	In this paper we introduce and study a model for electrical activity of cardiac membrane which incorporates only an inward and an outward current. This model is useful for three reasons: (1) Its simplicity, comparable to the FitzHugh-Nagumo model, makes it useful in numerical simulations, especially in two or three spatial dimensions where numerical efficiency is so important. (2) It can be understood analytically without recourse to numerical simulations. This allows us to determine rather completely how the parameters in the model affect its behavior which in turn provides insight into the effects of the many parameters in more realistic models. (3) It naturally gives rise to a one-dimensional map which specifies the action potential duration as a function of the previous diastolic interval. For certain parameter values, this map exhibits a new phenomenon--subcritical alternans--that does not occur for the commonly used exponential map.
Starting Page	99
Ending Page	104
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://homepage.divms.uiowa.edu/~mtchll/2Current.pdf
PubMed reference number	12909250v1
Volume Number	65
Issue Number	5
Journal	Bulletin of mathematical biology
Language	English
Access Restriction	Open
Subject Keyword	Diastole Dimensions Exhibits as Topic Population Parameter Tissue membrane alternan
Content Type	Text
Resource Type	Article

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