NDLI: Amlodipine plus perindopril was better than atenolol plus bendroflumethiazide for reducing complications in hypertension.

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Amlodipine plus perindopril was better than atenolol plus bendroflumethiazide for reducing complications in hypertension.

Content Provider	Semantic Scholar
Author	Zarnke, Kelly
Copyright Year	2006
Abstract	Dahlof B, Sever PS, Poulter NR, et al . Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005;366:895–906. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4]   Q In patients 40–79 years of age with hypertension and ⩾3 other cardiovascular (CV) risk factors, is amlodipine plus perindopril more effective than atenolol plus bendroflumethiazide for reducing CV outcomes? Clinical Impact Ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★★☆ ### ![Graphic][5] Design randomised controlled trial (Anglo-Scandinavian Cardiac Outcomes Trial–Blood Pressure Lowering Arm [ASCOT-BPLA]). ### ![Graphic][6] Allocation concealed.* ### ![Graphic][7] Blinding blinded (outcome assessors).* ### ![Graphic][8] Follow up period median 5.5 years. ### ![Graphic][9] Setting 686 family practices in the Nordic countries and 32 regional centres in the UK and Ireland. ### ![Graphic][10] Patients 19 257 patients 40–79 years of age (mean age 63 y, 77% men) who had hypertension and ⩾3 other CV risk factors. Exclusion criteria included previous myocardial infarction (MI), currently treated angina, and a cerebrovascular event … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DDahlof%26rft.auinit1%253DB.%26rft.volume%253D366%26rft.issue%253D9489%26rft.spage%253D895%26rft.epage%253D906%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252805%252967185-1%26rft_id%253Dinfo%253Apmid%252F16154016%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(05)67185-1&link_type=DOI [3]: /lookup/external-ref?access_num=16154016&link_type=MED&atom=%2Febmed%2F11%2F2%2F42.atom [4]: /lookup/external-ref?access_num=000231770000027&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif
Starting Page	42
Ending Page	42
Page Count	1
File Format	PDF HTM / HTML
DOI	10.1136/ebm.11.2.42
Alternate Webpage(s)	http://www.acpjc.org/Content/pdf/ACPJC-2006-144-2-032.pdf
PubMed reference number	17213072
Alternate Webpage(s)	https://doi.org/10.1136/ebm.11.2.42
Journal	Medline
Volume Number	11
Issue Number	2
Journal	Evidence-based medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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