NDLI: Lung Histological and Immunohistochemical Evaluation after Mesenteric Ischemia / Reperfusion in Rats

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Lung Histological and Immunohistochemical Evaluation after Mesenteric Ischemia / Reperfusion in Rats

Content Provider	Semantic Scholar
Author	Marques, Geraldo Magela Nogueira Rasslan, Roberto Belon, Alessandro Roderigo Massazo, Evaldo Utiyama Rasslan, Samir Montero, Edna Frasson De Souza
Copyright Year	2016
Abstract	The outbreak of inflammatory and apoptosis cascades in the acute lung injury that occurs after mesenteric ischemia and reperfusion (I/R m) in lung tissue which is targeted by cytokines and reactive substances oxygen produced in the mesenteric circulation are responsible for the endothelial barrier breakdown and the evolution of the process until the acute respiratory distress syndrome is installed [1-3]. The type of intervention to reverse the I/Rm process may affect the tissue response in target organs such as the lung. In hemorrhagic shock, pentoxifylline associated with hypertonic saline (7.5%), proved to be able to inhibit the activation of neutrophils and attenuate the production of TNF and interleukins and thus decrease the histological damage to the mesenteric territory and to target organs [3-6]. In this study, the aim was to assess the performance of the aforementioned substances in lung tissue in animals subjected to I/Rm by temporary occlusion of mesenteric vessels.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.juniperpublishers.com/oajs/pdf/OAJS.MS.ID.555565.pdf
Language	English
Access Restriction	Open
Subject Keyword	Acute Lung Injury Apoptosis Blood Vessel Catabolism Distress (novel) Mesenteric Lymphadenitis Mesenteric vascular insufficiency Mesentery Multiple Organ Failure Organ Oxygen Pentoxifylline Reperfusion Therapy Respiratory Distress Syndrome, Adult Respiratory Insufficiency Saline Solution, Hypertonic SalineOS Shock, Hemorrhagic Splanchnic Circulation Structure of parenchyma of lung substance
Content Type	Text
Resource Type	Article

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