NDLI: Centromere dynamics and chromosome evolution in marsupials.

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Centromere dynamics and chromosome evolution in marsupials.

Content Provider	Semantic Scholar
Author	O'Neill, Rachel J. Eldridge, Mark D. B. Metcalfe, Cushla J.
Copyright Year	2004
Abstract	The eukaryotic centromere poses an interesting evolutionary paradox: it is a chromatin entity indispensable to precise chromosome segregation in all eukaryotes, yet the DNA at the heart of the centromere is remarkably variable. Its important role of spindle attachment to the kinetochore during meiosis and mitosis notwithstanding, recent studies implicate the centromere as an active player in chromosome evolution and the divergence of species. This is exemplified by centromeric involvement in translocations, fusions, inversions, and centric shifts. Often species are defined karyotypically simply by the position of the centromere on certain chromosomes. Little is known about how the centromere, either as a functioning unit of chromatin or as a specific block of repetitive DNA sequences, acts in the creation of these types of chromosome rearrangements in an evolutionary context. Macropodine marsupials (kangaroos and wallabies) offer unique insights into current theories expositing centromere emergence during karyotypic diversification and speciation.
Starting Page	617
Ending Page	620
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jhered/95/5/10.1093/jhered/esh063/2/esh063.pdf?Expires=1492679146&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=SBsjnp6p~i7PaAzhVIirYXa01jCgnv7X1QjC~0Iw9aqUiohanI-KJBzEwOBZaWI-xCj79h9kmXT3vWNs64Bg-r5gxiOxTvu2rC52pG-KfrVBgNZblO1M3bUtrSzAM1Acd6oAaqwKYA1Yq5Oyi8UjlLZ1wcRMEOkzMh~tDBonM50plcAuy9xoCVh~7PlWormX9VKFfG4qua4iuYmasVkcIF182MwZ4aV4Zzw8NKJGp1y~BaKev62pZ4fbTlnw8X9bSShKK1P84hwRIzPeJM1wWUubu1eWMF~jMlWOYrEhpr7aI7HHYBPF9eLnWer7PXvoK87Hr17i~5wJmBABFlvBDA__
PubMed reference number	15388765v1
Volume Number	95
Issue Number	5
Journal	The Journal of heredity
Language	English
Access Restriction	Open
Subject Keyword	Centromere Chromosomal translocation Chromosome Segregation Chromosome inversion Chromosomes DNA Sequence Rearrangement Kinetochores Macropus Meiosis Mitosis Superorder Marsupalia (organism) Wallabies
Content Type	Text
Resource Type	Article

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