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Comparison of MR elastography and FibroScan for the non-invasive assessment of liver fibrosis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huwart, Laurent Peeters, Frank Sinkus, Ralph Annet, Laurence Salameh, Najat Beers, Bernard Van |
| Copyright Year | 2007 |
| Abstract | Results The measurement with FibroScan could not be performed in six patients who were obese or had ascites. These patients were excluded from the analysis and the final study group included thus 42 patients. According to the Metavir scoring system,12 patients (29%) had a stage of F0, 7 (17%) F1, 6 (14%) F2, 7 (17%) F3, and 10 (23%) F4. The MRE elasticity and viscosity, and FibroScan elasticity measurements are presented in Table 1. All these parameters increased according to the stage of liver fibrosis, and were correlated to the fibrosis stage: r = 0.95, P < .001 for MRE elasticity; r = 0.81, P < .001 for viscosity; and r = 0.72, P < .001 for FibroScan elasticity. The areas under the ROC curves are shown in Table 2. The most discriminant cut-off values of MRE elasticity were 2.4 kPa for F 1, 2.5 kPa for F 2, 3.1 kPa for F 3, and 4.3 kPa for F = 4. Discussion These results show that MRE is an accurate non-invasive method to stage liver fibrosis and that the measurements of elasticity obtained with MRE have a larger area under the ROC curve than the elasticity measurements obtained with FibroScan . The MRE elasticity measurements allowed to clearly separate the intermediate fibrosis stages and more precisely F2 from F1. This high accuracy is clinically important because, according to the American Association for the Study of Liver Diseases, patients with hepatitis C genotype-1 infection should be treated only when substantial fibrosis ( F2) is observed. The viscosity measurements were less accurate than the MRE elasticity measurements to stage liver fibrosis. The better results of MRE relative to FibroScan can be explained by two reasons. First, the volume assessed with MRE is much larger than the volume evaluated with ultrasound elastography. Second, MRE allows to assess the whole three-dimensional displacement vector induced by the mechanical waves. The results of the present study suggest that MRE is more accurate than FibroScan to stage liver fibrosis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cds.ismrm.org/ismrm-2007/files/00216.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
