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The Effects of Trimethadione and Its Metabolite on Human Liver Debrisoquine 4-Hydroxylase Activity In Vitro
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kobayashi, Shinichi Murray, Stephen Sesardic, Dorothea Boobis, Alan R. Davies, Donald Yasuharai, Hajime |
| Copyright Year | 2010 |
| Abstract | The effects of trimethadione (TMO) and its metabolite, dimethadione (DMO), on human liver microsomal debrisoquine 4-hydroxylase (cytochrome P-450db1) activity were studied. Inhibition curves showed that there is no significant decrease in the activity of debrisoquine 4-hydroxylase by TMO or DMO (0.1ƒÊM to 10mM). These data suggest that debrisoquine 4-hydroxylase in human liver is not responsible for N-demethylation of TMO, nor are TMO or DMO bound to its active site. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/sujms1989/2/1/2_1_27/_pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Debrisoquin Dimethadione DirectX Liver diseases Trimethadione Warhammer 40,000: Dark Millennium |
| Content Type | Text |
| Resource Type | Article |