NDLI: Efficacy of Intranasal Scopolamine Gel for Motion Sickness Treatment in Aviation Candidates

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Efficacy of Intranasal Scopolamine Gel for Motion Sickness Treatment in Aviation Candidates

Content Provider	Semantic Scholar
Author	Simmons, Rita G. Phillips, Jeffrey B. Lojewski, Renee A.
Copyright Year	2009
Abstract	Abstract : Results from preliminary studies indicate that intranasal scopolamine (INSCOP) has faster absorption, higher bioavailability and reliable therapeutic index than oral or transdermal forms. The objective of this study was to determine the efficacy of INSCOP for the treatment of motion-induced sickness and to estimate the rate of absorption. After completing baseline physiolgical, biological and cognitive assessments, 16 aviation candidates were given 0.4 mg of INSCOP and a placebo and were exposed to passive Coriolis cross-coupling. After exposure to provocative motion, subjects provided iterative physiological, biological, cognitive, and subjective sleepiness assessments. Analysis indicated that INSCOP was more efficacious than placebo as a motion sickness countermeasure during provocative motion. Analyses conducted on systolic blood pressure showed no significant effects, however, analysis of diastolic blood pressure did show significant effects after administration of INSCOP. Analysis of heart rate was significantly lower among participants in the INSCOP condition when compared to placebo. In addition, there were no significant cognitive performance or self report of sleepiness effects over time between conditions. Finally, blood concentration levels of scopolamine are provided. In conclusion, INSCOP is efficacious for the treatment of motion sickness, with no significant cognitive or sedative effects, and offers an excellent alternative for use in dynamic operational environments.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.dtic.mil/get-tr-doc/pdf?AD=ADA503148
Alternate Webpage(s)	http://www.dtic.mil/dtic/tr/fulltext/u2/a503148.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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