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Visible light-promoted ring-opening functionalization of unstrained cycloalkanols via inert C–C bond scission† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01763h ‡ ‡Dedicated to Professor Takahiko Akiyama on the occasion of his 60th birthday.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Dongping Mao, Jincheng Zhu, Chen |
| Copyright Year | 2018 |
| Abstract | Described herein is a novel, useful, visible light-promoted ring-opening functionalization of unstrained cycloalkanols. Upon scission of an inert cyclic C-C σ-bond, a set of medium- and large-sized rings are readily brominated under mild reaction conditions to afford the corresponding distal bromo-substituted alkyl ketones that are hard to synthesize otherwise. The products are versatile building blocks, which are easily converted to other valuable molecules in one-step operation. This protocol is also applicable to the unprecedented ring-opening cyanation and alkynylation of unstrained cycloalkanols. |
| Starting Page | 5805 |
| Ending Page | 5809 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c8sc01763h |
| PubMed reference number | 30079191 |
| Journal | Medline |
| Volume Number | 9 |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/articlepdf/2018/sc/c8sc01763h |
| Alternate Webpage(s) | https://doi.org/10.1039/c8sc01763h |
| Journal | Chemical science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
