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3,4-Methylenedioxymethamphetamine (MDMA), but not morphine, alters APP processing in the rat brain.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kálmán, János Bjelik, Annamária Hugyecz, Marietta Tímár, Júlia Zana, Marianna Fürst, Zsuzsanna Janka, Zoltán Rakonczay, Zoltán Horváth, Zoltán Pákáski, Magdolna |
| Copyright Year | 2007 |
| Abstract | The abuse of drugs such as opioids and 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') can have detrimental effects on the cognitive functions, but the exact molecular mechanism whereby these drugs promote neurodegeneration remains to be elucidated. The major purpose of the present pilot study was to determine whether the chronic in-vivo administration of morphine (10 mg/kg) or MDMA (1 mg/kg) to rats can alter the expression and processing of amyloid precursor protein (APP), the central molecule in the proposed pathomechanism of Alzheimer's disease. MDMA treatment significantly decreased the production of APP in the cytosolic fraction of the brain cortex. A concomitant 25% increase was found both in the beta-secretase (BACE) and APP mRNA levels (108%). In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production. These results indicate that the chronic use of 'ecstasy', but not morphine, may be harmful via a novel mode of action, i.e. by altering the APP expression and processing in the brain. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ijnp/10/2/10.1017/S146114570600650X/2/10-2-183.pdf?Expires=1492426900&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=ZCrBNXB8K1J0r-~vbZGmTAL8jS6c4W8Xuks0LClONandm1n1bH9qizYnU0lsvN7la6H1hXMXUNurEGm-Ys72xSd8YzmhR8czv8HX3qCwUkMreSkalh5L9MYebmLhXZA0VItFd0hq10b0jKP4C7fqm9lhWmmQTlGy1auxu6rXPMD3uiMoZFhFUgty9yynDOxPsL0-aF-JZqGj49u3JPMObG5qNjnQrvQseUhVNluTuBq3KKczZGySZamWiT~nnqUjVTyRMA2sjEgm9zx9GHoW7si89iiHVTGZ4bkc3DkWzd0-GkCPozl3PPdNcz5MRaKHS0N4PQ5qDAKr4TKu4lvt1g__ |
| Alternate Webpage(s) | http://ijnp.oxfordjournals.org/content/ijnp/10/2/183.full.pdf |
| PubMed reference number | 16487451v1 |
| Volume Number | 10 |
| Issue Number | 2 |
| Journal | The international journal of neuropsychopharmacology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | APP protein, human Alzheimer's Disease Amyloid beta-Protein Precursor BACE1 wt Allele Cognition Disorders Drug abuse Ecstasy - drug Morphine OPIOID ANALGESICS beta Thalassemia mg/kg nervous system disorder secretase |
| Content Type | Text |
| Resource Type | Article |
