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Laser-illuminated nanohole arrays for multiplex plasmonic microarray sensing.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lesuffleur, Antoine Im, Hyungsoon Lindquist, Nathan C. Lim, Kwan Seop Oh, Sang-Hyun |
| Copyright Year | 2008 |
| Abstract | Surface plasmon resonance (SPR) imaging is a powerful technique for high-throughput, real-time, label-free characterization of molecular interactions in a microarray format. In this paper, we demonstrate SPR imaging with nanohole arrays illuminated by a laser source. Periodic nanoholes couple incident photons into SPs, obviating the need for the prism used in conventional SPR instruments, while a laser source provides the intensity, stability and spectral coherence to improve the detection sensitivity. The formation of a self-assembled monolayer of alkanethiolates on gold changed the laser transmission by more than 35%, and binding kinetics were measured in parallel from a 5 x 3 microarray of nanohole sensors. These results demonstrate the potential of nanohole sensors for high-throughput SPR imaging on microarrays. |
| File Format | PDF HTM / HTML |
| DOI | 10.1364/OE.16.000219 |
| PubMed reference number | 18521151 |
| Journal | Medline |
| Volume Number | 16 |
| Issue Number | 1 |
| Alternate Webpage(s) | https://scholar.harvard.edu/files/him/files/2008_opt_exp.pdf |
| Alternate Webpage(s) | https://doi.org/10.1364/OE.16.000219 |
| Journal | Optics express |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
