Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats

Content Provider	Semantic Scholar
Author	Vale-Martı́nez, Anna Guillazo-Blanch, Gemma Martí-Nicolovius, Margarita Nadal, Roser Arévalo-García, Rosa Morgado-Bernal, Ignacio
Copyright Year	2001
Abstract	Abstract. Previous experiments on two-way active avoidance have shown conflicting results after nucleus basalis magnocellularis lesion: disrupting effects with electrolytic lesions and facilitative effects with excitotoxic lesions. To resolve this issue, in this experiment, Wistar rats received pre-training bilateral electrolytic or ibotenic acid lesions and were trained in a massed two-way active avoidance conditioning. In order to test the long-term retention of the learned response, one additional session was conducted 10 days after the acquisition. Results showed that whereas electrolytic lesions did not affect the acquisition, ibotenic acid lesions enhanced it. Retention of active avoidance response was impaired by both electrolytic and ibotenic lesions of the NBM. These results suggest a role of the NBM in the memory consolidation and/or retrieval of two-way active avoidance.
Starting Page	52
Ending Page	66
Page Count	15
File Format	PDF HTM / HTML
DOI	10.1007/s00221-001-0917-4
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/s00221-001-0917-4
PubMed reference number	11797084
Alternate Webpage(s)	https://doi.org/10.1007/s00221-001-0917-4
Journal	Medline
Volume Number	142
Journal	Experimental Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article