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Gene expression of the p 16 INK 4 aRb and p 19 Arf-p 53-p 21 Cip / Waf 1 signaling pathways in the regulation of hematopoietic stem cell aging by ginsenoside Rg 1
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yue, Zhicao Rong, J. D. Ping, Wong Ya Bing, Yan Feng, Leilei Ya-Ping, Wei |
| Copyright Year | 2014 |
| Abstract | The elucidation of the molecular mechanisms underlying the effects of traditional Chinese medicines in clinical practice is a key step toward their worldwide application, and this topic is currently a subject of intense research interest. Rg1, a component of ginsenoside, has recently been shown to perform several pharmacological functions; however, the underlying mechanisms of these effects remain unclear. In the present study, we investigated whether Rg1 has an anti-senescence effect on hematopoietic stem cells (HSCs) and the possible molecular mechanisms driving any effects. The results showed that Rg1 could effectively delay tert-butyl hydroperoxide (t-BHP)-induced senescence and inhibit gene expression in the p16INK4a-Rb and p19Arf-p53-p21Cip/ Waf1 signaling pathways in HSCs. Our study suggested that these two signaling pathways might be potential targets for elucidating the |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.funpecrp.com.br/gmr/year2014/vol13-4/pdf/gmr3686.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
