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DBSA catalyzed, one-pot three-component “on water” green protocol for the synthesis of 2,3-disubstituted 4-thiazolidinones
| Content Provider | Semantic Scholar |
|---|---|
| Author | Prasad, Davinder Preetam, Amreeta Nath, Mahendra |
| Copyright Year | 2012 |
| Abstract | A simple and environmentally benign one-pot three-component tandem synthesis of a series of novel 4-thiazolidinones has been accomplished “on water” by reacting aliphatic or aromatic primary amines with thioglycolic acid and a wide range of aromatic aldehydes at ambient temperature using p-dodecylbenzenesulfonic acid (DBSA) as a Bronsted acid-surfactant combined catalyst. The unique ability of the catalyst has been utilised to form emulsion droplets with organic substrates in aqueous medium whose interior core is hydrophobic enough to exclude the water molecules generated during the rate limiting dehydration step of the reaction. This protocol worked well with a variety of substrates and the desired products were obtained in fairly good yields. |
| Starting Page | 3133 |
| Ending Page | 3140 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C2RA20171B |
| Volume Number | 2 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ra/c2/c2ra20171b/c2ra20171b.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C2RA20171B |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
